CRIECNN: Ensemble convolutional neural network and advanced feature extraction methods for the precise forecasting of circRNA-RBP binding sites.

Circular RNAs (circRNAs) have surfaced as important non-coding RNA molecules in biology. Understanding interactions between circRNAs and RNA-binding proteins (RBPs) is crucial in circRNA research. Existing prediction models suffer from limited availability and accuracy, necessitating advanced approaches. In this study, we propose CRIECNN (Circular RNA-RBP Interaction predictor using an Ensemble Convolutional Neural Network), a novel ensemble deep learning model that enhances circRNA-RBP binding site prediction accuracy. CRIECNN employs advanced feature extraction methods and evaluates four distinct sequence datasets and encoding techniques (BERT, Doc2Vec, KNF, EIIP). The model consists of an ensemble convolutional neural network, a BiLSTM, and a self-attention mechanism for feature refinement. Our results demonstrate that CRIECNN outperforms state-of-the-art methods in accuracy and performance, effectively predicting circRNA-RBP interactions from both full-length sequences and fragments. This novel strategy makes an enormous advancement in the prediction of circRNA-RBP interactions, improving our understanding of circRNAs and their regulatory roles.

Maximizing the information throughput of ultra-wideband fiber-optic communication systems.

Maximized information rates of ultra-wideband (typically, beyond 100~nm modulated bandwidth) lumped-amplified fiber-optic communication systems have been thoroughly examined accounting for the wavelength dependencies of optical fiber parameters in conjunction with the impact of the inelastic inter-channel stimulated Raman scattering (SRS). Three strategies to maximize point-to-point link throughput were proposed: optimizations of non-uniformly and uniformly distributed launch power per channel and the optimization based on adjusting to the target 3 dB ratio between the power of linear amplified spontaneous emission and nonlinear interference noise. The results clearly emphasize the possibility to approach nearly optimal system performance by means of implementing pragmatic engineering sub-optimal optimization strategies.